Table 1.

A summary of optical coherence tomography angiography metrics used in selected previous and ongoing clinical trials for diabetic retinopathy, diabetic macular edema, or diabetic macular ischemia, including primary endpoint and measurement. Please note that this is not an exhaustive list.

Trial	Primary endpoint	Indication	Measurement	Trial status

CORISMAP NCT02876744	Macular and peripheral ischemia	DR	Correlation of macular and peripheral ischemia using OCTA	Completed (Jan 2021)
ICOD NCT04038125	Vessel perfusion	DME	Capillary reperfusion over 6 months by OCTA	Unknown
HORNBILL NCT04424290(Chong et al., 2022)	FAZ size	DMI	Change from baseline of the size of the FAZ using OCTA in superficial and combined vascular complex	Completed (April 2023)
NCT03922932	Non-perfusion areas (extrafoveal avascular area)	DR	PR-OCTA measure of non-perfusion (mm²) over 3 years Non-PR-OCTA measure of retinal non-perfusion (mm²) over 1 year Non-PR-OCTA of retinal neovascularization (mm²) over 1 year	Recruiting
NCT04660006	Vessel density/perfusion	DR/DME	Change from baseline in retinal vessel density at 3 months by OCTA Change from baseline in retinal perfusion density at 3 months by OCTA	Unknown
	FAZ size/circularity		Change from baseline in FAZ size at 3 months by OCTA
NCT03765112	Perfusion density	DR	Perfusion density by OCTA	Recruiting
	FAZ size		FAZ size at 6 months by OCTA
PROPER	Vascular density	DR	Change in vascular density of retinal capillary plexuses at 3, 6, 9, and 12 months by OCTA	RActive, not recruiting
NCT04674254	FAZ size		Change in FAZ size at 3, 6, 9, and 12 months by OCTA
PARTRIDGE NCT04919499	FAZ size	DMI	Change from baseline in FAZ size using OCTA at 12, 16, and 20 weeks	Active, not recruiting

Trial statuses are accurate as of 8 August 2023. DME, diabetic macular edema; DMI, diabetic macular ischemia; DR, diabetic retinopathy; FAZ, foveal avascular zone; OCTA, optical coherence tomography angiography; PR-OCTA, projection-resolved optical coherence tomography angiography.