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CIR and intracranial PFS in the CNS-overall-mets population. (A) CIR of CNS PD; (B) CIR of non-CNS PD and death; and (C) intracranial PFS. CIR, cumulative incidence rate; CNS-overall-mets, CNS-overall population with baseline brain metastases; HR, hazard ratio; NE, not evaluable; PD, progressive disease; PFS, progression-free survival.
