Table 2. Wald type II chi-square statistics of the linear mixed models for each HRQOL measure.

Variables	χ 2	df	P value
Physical Health (PCS)
Time	95.024	1	< .001*
Gender	15.049	1	< .001*
Time × gender	4.843	1	.028*
Comorbidity burden:
Total comorbidity conditions	16.819	2	< .001*
Charlson comorbidity categories	12.798	2	.002*
Comorbidity burden × gender:
Total comorbidity conditions	9.448	2	.009*
Charlson comorbidity categories	3.715	2	.156
Comorbidity burden × time:
Total comorbidity conditions	0.348	2	.840
Charlson comorbidity categories	0.990	2	.610
Mental health (MCS)
Time	44.794	1	< .001*
Gender	1.351	1	.245
Time × gender	0.206	1	.650
Comorbidity burden:
Total comorbidity conditions	2.143	2	.343
Charlson comorbidity categories	4.787	2	.091
Comorbidity burden × gender:
Total comorbidity conditions	2.775	2	.250
Charlson comorbidity categories	5.135	2	.077
Comorbidity burden × time:
Total comorbidity conditions	4.823	2	.090
Charlson comorbidity categories	2.344	2	.310
Disease-specific HRQoL (SAQ)
Time	248.309	1	< .001*
Gender	15.787	1	< .001*
Time × gender	1.564	1	.211
Comorbidity burden:
Total comorbidity conditions	2.035	2	.362
Charlson comorbidity categories	7.115	2	.029*
Comorbidity burden × gender:
Total comorbidity conditions	13.761	2	.001*
Charlson comorbidity categories	3.132	2	.209
Comorbidity burden × time
Total comorbidity conditions	6.877	2	.032*
Charlson comorbidity categories	0.906	2	.636

*P values < 0.05 were considered significant.