TABLE 1.
Estimates of size and power for three log rank tests under simulation design 1 with clusters and heavy (50%) censoring. Positive/Negative cluster size informativeness indicates that larger/smaller clusters tended to have longer survival times. Group size informativeness indicates which group tended to be over-represented in clusters with longer survival times. LR = log rank, SLR = stratified log rank, CWLR = cluster size-weighted log rank, GWLR = group size-weighted log rank, and Frailty = frailty model
Informativeness | Power | ||||||
---|---|---|---|---|---|---|---|
Group Size | Cluster Size | Test | Size | ||||
None | None | LR | 0.054 | 0.10 | 0.22 | 0.44 | 0.67 |
SLR | 0.048 | 0.16 | 0.49 | 0.83 | 0.97 | ||
CWLR | 0.061 | 0.11 | 0.22 | 0.42 | 0.64 | ||
GWLR | 0.055 | 0.14 | 0.37 | 0.68 | 0.89 | ||
Frailty | 0.045 | 0.17 | 0.50 | 0.84 | 0.98 | ||
Positive | LR | 0.044 | 0.09 | 0.23 | 0.45 | 0.67 | |
SLR | 0.051 | 0.17 | 0.50 | 0.85 | 0.97 | ||
CWLR | 0.057 | 0.08 | 0.17 | 0.30 | 0.47 | ||
GWLR | 0.055 | 0.11 | 0.24 | 0.47 | 0.70 | ||
Frailty | 0.042 | 0.17 | 0.51 | 0.86 | 0.98 | ||
Negative | LR | 0.043 | 0.11 | 0.33 | 0.62 | 0.84 | |
SLR | 0.050 | 0.16 | 0.48 | 0.81 | 0.96 | ||
CWLR | 0.055 | 0.10 | 0.26 | 0.48 | 0.69 | ||
GWLR | 0.055 | 0.16 | 0.47 | 0.78 | 0.95 | ||
Frailty | 0.057 | 0.16 | 0.50 | 0.84 | 0.97 | ||
Group 0 | None | LR | 1.000 | 1.00 | 1.00 | 1.00 | 1.00 |
SLR | 0.058 | 0.13 | 0.36 | 0.70 | 0.90 | ||
CWLR | 1.000 | 1.00 | 1.00 | 1.00 | 1.00 | ||
GWLR | 0.055 | 0.10 | 0.26 | 0.53 | 0.79 | ||
Frailty | 0.095 | 0.29 | 0.61 | 0.89 | 0.97 | ||
Positive | LR | 1.000 | 1.00 | 1.00 | 1.00 | 1.00 | |
SLR | 0.052 | 0.11 | 0.35 | 0.63 | 0.85 | ||
CWLR | 0.994 | 1.00 | 1.00 | 1.00 | 1.00 | ||
GWLR | 0.057 | 0.08 | 0.20 | 0.37 | 0.60 | ||
Frailty | 0.074 | 0.23 | 0.53 | 0.79 | 0.95 | ||
Negative | LR | 1.000 | 1.00 | 1.00 | 1.00 | 1.00 | |
SLR | 0.045 | 0.14 | 0.41 | 0.75 | 0.93 | ||
CWLR | 1.000 | 1.00 | 1.00 | 1.00 | 1.00 | ||
GWLR | 0.053 | 0.11 | 0.33 | 0.59 | 0.85 | ||
Frailty | 0.097 | 0.32 | 0.68 | 0.91 | 0.98 | ||
Group 1 | None | LR | 1.000 | 1.00 | 1.00 | 0.99 | 0.97 |
SLR | 0.051 | 0.13 | 0.37 | 0.70 | 0.91 | ||
CWLR | 1.000 | 1.00 | 0.98 | 0.94 | 0.83 | ||
GWLR | 0.058 | 0.14 | 0.33 | 0.59 | 0.81 | ||
Frailty | 0.090 | 0.07 | 0.22 | 0.54 | 0.81 | ||
Positive | LR | 1.000 | 1.00 | 0.98 | 0.95 | 0.86 | |
SLR | 0.053 | 0.15 | 0.38 | 0.67 | 0.89 | ||
CWLR | 1.000 | 0.98 | 0.94 | 0.87 | 0.72 | ||
GWLR | 0.052 | 0.12 | 0.25 | 0.46 | 0.63 | ||
Frailty | 0.075 | 0.08 | 0.25 | 0.52 | 0.78 | ||
Negative | LR | 1.000 | 1.00 | 0.97 | 0.86 | 0.64 | |
SLR | 0.048 | 0.14 | 0.43 | 0.73 | 0.94 | ||
CWLR | 1.000 | 1.00 | 0.98 | 0.89 | 0.72 | ||
GWLR | 0.066 | 0.16 | 0.40 | 0.67 | 0.88 | ||
Frailty | 0.093 | 0.07 | 0.25 | 0.57 | 0.85 |