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| Toxic effect and grade | Signs | |
|---|---|---|
| Diarrhea | ||
| I | Soft stools, response to dietary modification | |
| II | 3—7 watery stools per day, < 2 days | |
| III | >7 watery stools a day | |
| IV | Intractable or bloody, requires hospitalization | |
| Vomiting | ||
| I | sporadic, self-limiting | |
| II | 1–5 episodes a day, < 2 days | |
| III | 6–10 episodes per day | |
| IV | Intractable, requires hospitalization | |
| Neutropenia | ||
| I | Neutrophils < 3.5 × 109/l | |
| II | Neutrophils < 2.0 × 109/l | |
| III | Neutrophils < 1.0 × 109/l | |
| IV | Neutrophils < 0.5 × 109/l | |
