Table 2.

Baseline characteristics of Evolut-R, Portico and Lotus patients.

Variables	Evolut-R	Portico	Lotus	p-value
N	124 (53.4%)	78 (33.6%)	30 (12.9%)
Age (years)	86.6 $\pm$ 6.7	83.8 $\pm$ 7.1	78.0 $\pm$ 8.2	0.001
Female sex	68 (54.8%)	49 (62.8%)	14 (46.7%)	0.274
Hypertension	85 (68.5%)	61 (78.2%)	23 (76.7%)	0.285
Diabetes	38 (30.6%)	14 (17.9%)	3 (10.0%)	0.020
Dyslipidemia	43 (34.7%)	39 (50.0%)	10 (33.3%)	0.072
COPD	19 (15.3%)	11 (4.7%)	5 (15.7%)	0.940
Coronary artery disease	42 (33.9%)	21 (26.9%)	13 (43.3%)	0.247
Prior CABG	9 (7.3%)	5 (6.4%)	3 (10.0%)	0.785
Prior AMI	13 (10.5%)	9 (11.5%)	4 (13.3%)	0.900
STS score (%)	5.4 $\pm$ 3.2	5.0 $\pm$ 2.9	3.4 $\pm$ 2.0	0.005
Creatinine clearance (mL/min/1.73 $m^2$)	51.9 $\pm$ 21.1	52.0 $\pm$ 22.2	59.1 $\pm$ 17.8	0.226
Haemoglobin (g/dL)	12.1 $\pm$ 1.7	11.6 $\pm$ 1.5	12.7 $\pm$ 1.7	0.018
Ejection fraction (%)	55.2 $\pm$ 11.9	55.9 $\pm$ 11.2	55.7 $\pm$ 10.2	0.932
Mean aortic gradient (mmHg)	46.4 $\pm$ 16.1	43.5 $\pm$ 14.3	50.8 $\pm$ 17.9	0.109
AR $\ge$moderate	27 (21.8%)	15 (19.2%)	6 (20.0%)	0.905
LM height (mm)	15.1 $\pm$ 3.8	13.8 $\pm$ 3.6	15.5 $\pm$ 4.1	0.050
RCA height (mm)	18.3 $\pm$ 3.7	16.8 $\pm$ 3.6	18.1 $\pm$ 3.5	0.015
Annulus min diameter (mm)	20.9 $\pm$ 2.8	20.3 $\pm$ 2.2	21.6 $\pm$ 2.2	0.066
Annulus max diameter (mm)	26.8 $\pm$ 3.1	25.6 $\pm$ 2.7	27.2 $\pm$ 2.2	0.004
Annulus mean diameter (mm)	23.8 $\pm$ 2.8	23.0 $\pm$ 2.3	24.4 $\pm$ 2.0	0.014
Annulus perimeter (mm)	75.6 $\pm$ 8.5	72.6 $\pm$ 6.9	77.6 $\pm$ 6.1	0.004
Annulus area (${\mathrm{mm}}^2$)	438.5 $\pm$ 101.1	396.7 $\pm$ 101.1	366.0 $\pm$ 201.9	0.003
Sinus of Valsalva diameter (mm)	32.7 $\pm$ 4.3	31.2 $\pm$ 3.9	32.7 $\pm$ 4.4	0.162
Calcium volume 800 HU (${\mathrm{mm}}^3$)	299. 4 [172.2–526.5]	276.5 [169.3–479.8]	519.2 [204.7–802.2]	0.187
Aortic angulation (°)	50.9 $\pm$ 11.3	47.9 $\pm$ 9.5	50.9 $\pm$ 10.9	0.164
Index of eccentricity	0.22 $\pm$ 0.07	0.20 $\pm$ 0.07	0.21 $\pm$ 0.05	0.163
Calcification at LVOT	71 (57.3%)	52 (66.7%)	11 (36.7%)	0.018
Calcification at annulus	105 (84.7%)	56 (71.8%)	27 (90%)	0.031
Calcification in annulus and LVOT	52 (41.9%)	30 (38.5%)	8 (26.7%)	0.305
Calcification number	1.36 $\pm$ 0.72	1.51 $\pm$ 0.78	1.40 $\pm$ 0.72	0.378
Major calcification diameter (mm)	4.5 $\pm$ 2.4	5.2 $\pm$ 3.0	3.7 $\pm$ 2.4	0.024
LVOT diameter (mm)	65 (52.4%)	46 (59.0%)	12 (40.0%)	0.205
Ascending aorta (mm)	19.3 $\pm$ 2.8	18.9 $\pm$ 2.3	20.5 $\pm$ 4.3	0.109

AMI, acute myocardial infarction; AR, aortic regurgitation; CABG, coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease; HU, Hounsfield Units; LM, left main; LVOT, left ventricular outflow tract; RCA, right coronary artery; STS, Society of Thoracic Surgeons.