FIGURE 7.

High glucose metabolite abundance patterns are associated with median RLS under CR condition. The box plot depicts the top metabolites significantly altered in the positively responding (POS) group, compared to the (A) non-responding (NON) and (B) negatively responding (NEG) groups. (C) Positive significant correlation of n-formylmethionine and (D) non-significant correlation of methionine with median RLS. The Y-axis denotes the abundance level of each metabolite identified under high glucose condition, and the X-axis represents the median RLS, determined under CR condition. Each color point represents an individual strain. The gray area represents a 95% confidence interval. The complete list of metabolites with normalized abundance or regression slopes, and p values can be found in Supplementary Material S2.