Table 4.
Subgroup analysis between SIRI and bone turnover markers.
| N | β-CTXa | P1NPa | |
|---|---|---|---|
| β (95% CI) p-value | β (95% CI) p-value | ||
| Age, years, N (%) | |||
| >50, ≤70 | 420 | −0.04 (−0.05, −0.02) <0.001 | −3.53 (−5.27, −1.78) <0.001 |
| >70 | 312 | −0.04 (−0.06, −0.02) <0.001 | −4.47 (−6.43, −2.51) <0.001 |
| Sex, N (%) | |||
| Female | 486 | Reference | Reference |
| Male | 246 | −0.03 (−0.05, 0.01) 0.007 | −3.59 (−5.94, −1.24) 0.003 |
| BMI, kg/m2, N (%) | |||
| ≤18.5 | 73 | −0.03 (−0.05, −0.01) 0.004 | −2.50 (−4.88, −0.12) 0.05 |
| >18.5, ≤23.9 | 362 | −0.04 (−0.06, −0.02) <0.001 | −4.28 (−6.54, −2.03) <0.001 |
| >23.9 | 297 | −0.04 (−0.06, −0.02) <0.001 | −3.45 (−5.49, −1.40) 0.001 |
| Smoke, N (%) | |||
| No | 684 | −0.04 (−0.05, −0.03) <0.001 | −3.88 (−5.17, −2.60) <0.001 |
| Yes | 48 | Reference | Reference |
| Drink, N (%) | |||
| No | 704 | −0.04 (−0.05, −0.03) <0.001 | −3.76 (−5.12, −2.39) <0.001 |
| Yes | 28 | Reference | Reference |
| Hypertension, N (%) | |||
| No | 642 | −0.03 (−0.05, −0.02) <0.001 | −3.48 (−4.81, −2.14) <0.001 |
| Yes | 90 | −0.08 (−0.12, −0.04) <0.001 | −5.04 (−10.27, 0.19) 0.06 |
| Diabetes, N (%) | |||
| No | 702 | −0.04(−0.05, −0.03) <0.001 | −3.68 (−5.12, −2.46) <0.001 |
| Yes | 30 | Reference | Reference |
| CCI, N (%) | |||
| 0 | 655 | Reference | Reference |
| ≥1 | 77 | −0.05 (−0.07, −0.02) 0.002 | −4.50 (−7.20, −1.80) 0.002 |
| TC, mmol/L | |||
| Low | 249 | −0.04 (−0.05, −0.02) <0.001 | −3.12 (−5.35, −0.90) 0.006 |
| High | 325 | −0.04 (−0.05, −0.02) <0.001 | −4.10 (−5.67, −2.54) <0.001 |
| HDL, mmol/L | |||
| Low | 292 | −0.04 (−0.06, −0.03) <0.001 | −3.73 (−5.92, −1.55) 0.001 |
| High | 282 | −0.03 (−0.05, −0.02) <0.001 | −0.04 (−3.27, −1.66) <0.001 |
| Calcium, mmol/L | |||
| Low | 334 | −0.03 (−0.05, −0.02) <0.001 | −3.10 (−5.34, −0.86) 0.007 |
| High | 395 | −0.04 (−0.05, −0.02) <0.001 | −3.93 (−5.52, −2.34) <0.001 |
| Platelet count, ×109/L | |||
| Low | 367 | −0.04 (−0.06, −0.03) <0.001 | −3.82 (−5.95, −1.70) <0.001 |
| High | 365 | −0.03 (−0.05, −0.02) <0.001 | −3.46 (−5.09, −1.84) <0.001 |
aPatients were stratified based on age, sex, BMI, smoking status, alcohol consumption, CCI, hypertension, diabetes, HDL, TC, calcium, and platelet count, and additional covariates not included in the stratification were adjusted for in the analysis. BMI, body mass index; TC, total cholesterol; HDL, high-density lipoprotein; β-CTX, beta-C-terminal telopeptide of type I collagen; P1NP, procollagen type I N-terminal propeptide; SIRI, systemic inflammatory response index; CCI, Charlson comorbidity index.