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. 2024 Jul 10;631(8022):913–919. doi: 10.1038/s41586-024-07680-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Post-mortem AD brain with PMI and freeze-thaw step that preceded high pressure freezing (PMI-FT-HPF). b, Post-mortem non-demented control brain (Control human PMI-FT-HPF). c, Mouse model of β-amyloidosis brain (App^NL-G-F) prepared with PMI-FT-HPF. d, Mouse model of β-amyloidosis (App^NL-G-F). Sample prepared without post-mortem interval and freeze-thaw step (App^NL-G-F-HPF) (see Leistner et al. for details)³⁰. Dark purple arrowhead, outer mitochondrial membrane. Light purple arrowhead, inner mitochondrial membrane. Light purple asterisk, diluted mitochondrial matrix. Dark green arrowhead, sub-cellular membrane compartment. Light green arrowhead, burst membrane. Orange arrowhead, actin filament. Yellow arrowhead, microtubule. Brown arrowhead, myelin sheath. White arrowhead, knife damage or surface ice contamination. Scale bar, 10 nm.