Fig. 2.

Concordance of nanopore sequencing-based classification of ultrasonic aspirator-derived tumor material with the corresponding 2016 WHO CNS reference diagnosis. (A) All samples with classification scores meeting the platform-specific cut-off of 0.2 (15/19, 79%) were correctly classified (true positives). (B) In 2/19 (11%) cases, the score was below the recommended cut-off but classification was still correct (false negatives). (C) 2/19 (11%) cases had discordant results with scores that were below the nanopore-specific threshold (true negatives), resulting in 100% specificity and 79% sensitivity for a classification score above the cut-off to predict correct classification