Table 1.
MR results of causal links between gut microbiome and outcome
| Classification | Bacterial traits | Nsnp | Methods | HR (95% CI) | p-value |
|---|---|---|---|---|---|
| Family | Oxalobacteraceae.id.2966 | 1 | Wald ratio | 3.45 (1.03, 11.59) | 0.0454 |
| Veillonellaceae.id.2172 | 4 | Inverse variance weighted (fixed effects) | 8.04 (2.53, 25.56) | 0.0004 | |
| Inverse variance weighted (multiplicative random effects) | 8.04 (2.73, 23.70) | 0.0002 | |||
| Weighted median | 9.76 (2.07, 46.07) | 0.0040 | |||
| MR Egger | 0.58 (0.00, 504.24) | 0.8907 | |||
| Simple median | 12.27 (2.72, 55.26) | 0.0011 | |||
| Genus | Eubacteriumhalliigroup.id.11338 | 3 | Inverse variance weighted (fixed effects) | 5.34 (1.33, 21.51) | 0.0184 |
| Inverse variance weighted (multiplicative random effects) | 5.34 (1.28, 22.23) | 0.0213 | |||
| Weighted median | 3.03 (0.46, 20.01) | 0.2486 | |||
| MR Egger | 0.04 (0.00, 724.06) | 0.8603 | |||
| Simple median | 3.17 (0.45, 22.23) | 0.2457 | |||
| Eubacteriumnodatumgroup.id.11297 | 5 | Inverse variance weighted (fixed effects) | 1.79 (1.13, 2.84) | 0.0137 | |
| Inverse variance weighted (multiplicative random effects) | 1.79 (1.03, 3.11) | 0.0391 | |||
| Weighted median | 1.54 (0.81, 2.95) | 0.1890 | |||
| MR Egger | 10.36 (1.17, 91.48) | 0.1261 | |||
| Simple median | 1.56 (0.79, 3.10) | 0.1996 | |||
| Butyrivibrio.id.1993 | 5 | Inverse variance weighted (fixed effects) | 0.56 (0.34, 0.93) | 0.0252 | |
| Inverse variance weighted (multiplicative random effects) | 0.56 (0.36, 0.88) | 0.0112 | |||
| Weighted median | 0.61 (0.30, 1.25) | 0.1758 | |||
| MR Egger | 1.34 (0.13, 13.81) | 0.8218 | |||
| Simple median | 0.61 (0.31, 1.20) | 0.1521 | |||
| Catenibacterium.id.2153 | 1 | Wald ratio | 3.92 (1.43, 10.76) | 0.0079 | |
| Faecalibacterium.id.2057 | 2 | Inverse variance weighted (fixed effects) | 6.04 (1.02, 35.67) | 0.0472 | |
| Inverse variance weighted (multiplicative random effects) | 6.04 (4.03, 9.05) | 0.0000 | |||
| Olsenella.id.822 | 3 | Inverse variance weighted (fixed effects) | 2.31 (1.22, 4.37) | 0.0102 | |
| Inverse variance weighted (multiplicative random effects) | 2.31 (1.64, 3.25) | 0.0000 | |||
| Weighted median | 2.42 (1.08, 5.43) | 0.0323 | |||
| MR Egger | 3.80 (0.41, 35.01) | 0.4483 | |||
| Simple median | 2.53 (1.09, 5.85) | 0.0305 | |||
| Oxalobacter.id.2978 | 1 | Wald ratio | 3.30 (1.02, 10.61) | 0.0454 | |
| Ruminiclostridium5.id.11355 | 4 | Inverse variance weighted (fixed effects) | 5.64 (1.68, 19.01) | 0.0052 | |
| Inverse variance weighted (multiplicative random effects) | 5.64 (3.51, 9.08) | 0.0000 | |||
| Weighted median | 6.18 (1.41, 27.02) | 0.0156 | |||
| MR Egger | 7.59 (0.06, 895.66) | 0.4926 | |||
| Simple median | 6.26 (1.47, 26.57) | 0.0130 | |||
| Phylum | Proteobacteria.id.2375 | 3 | Inverse variance weighted (fixed effects) | 8.29 (2.03, 33.92) | 0.0033 |
| Inverse variance weighted (multiplicative random effects) | 8.29 (4.06, 16.93) | 0.0000 | |||
| Weighted median | 8.97 (1.55, 51.84) | 0.0143 | |||
| MR Egger | 80.47 (0.12, 556.72) | 0.4139 | |||
| Simple median | 11.29 (1.59, 79.99) | 0.0152 |