Table 1.
Sociodemographic, genetic ancestry, anthropometric, and clinical characterization of SABE cohort.
| Variables | All individuals | Normal weight | Excessive weight | p-value |
|---|---|---|---|---|
| N | 1024 | 280 (27.34%) | 744 (72.65%) | – |
| Male/female (%) | 365 (35.71%)/657(64.28%) | 115 (41.21%)/164(58.78%) | 250 (33.64%)/493(66.35%) | 0.024 |
| Age (years) | 71.31 (59–99) | 74.36 (60–99) | 68.97 (59–98) | < 0.001 |
| Ancestry frequencies | ||||
| European | 72.53% | 72.08% | 72.69% | 0.79 |
| African | 17.89% | 16.13% | 18.55% | 0.04 |
| Asian | 2.80% | 5.26% | 1.88% | 0.22 |
| Native American | 6.75% | 6.49% | 6.85% | 0.82 |
| BMI (kg/m2) | 27.45 (15.13–53.61) | 22.83 (15.13–25) | 29.2 (25.01–53.61) | < 0.001 |
| WC (cm) | 94 (62–142) | 82 (64–99) | 98 (62–142) | < 0.001 |
| Hypertension (%) | 702 (68.55%) | 167 (59.64%) | 535 (71.9%) | < 0.001 |
| SBP (mmHg) | 138 (88–250) | 135 (88–242) | 138.5 (91–250) | 0.13 |
| DBP (mmHg) | 79 (49–125) | 76 (50–117) | 80 (49–125) | < 0.001 |
| HDL (mg/dl) | 48 (19–133) | 52 (20–124) | 46 (19–133) | < 0.001 |
| LDL (mg/dl) | 126 (28–299) | 126 (41–226) | 125 (28–299) | 0.89 |
| TC (mg/dl) | 204 (86–388) | 204 (89–321) | 204 (86–388) | 0.94 |
| TG (mg/dl) | 115 (25–1283) | 101 (25–436) | 121.5 (34–1283) | < 0.001 |
| T2D (%) | 259 (25.29%) | 53 (18.92%) | 206 (27.68%) | 0.004 |
| FPG (mg/dl) | 88 (80–102) | 85 (78–95) | 90 (82–105.8) | < 0.001 |
| Hb1Ac (%) | 5.8 (4.8–13.7) | 5.7 (4.9–13.6) | 5.8 (4.8–13.7) | < 0.001 |
| hsCRP (mg/l) | 2.34 (0.14–141) | 1.43 (0.14–61.5) | 2.83 (0.14–141) | < 0.001 |
| Ex/current smoker | 375 (36.62%)/121 (11.81%) | 110 (39.28%)/52 (18.57%) | 265 (35.61%)/69 (9.27%) | < 0.001 |
Results are presented as medians and extreme values (minimum and maximum). P-values indicate differences between normal weight (BMI < 25 kg/m2) and overweight/obesity (BMI ≥ 25 kg/m2) individuals according to Mann–Whitney test for non-parametric variables and the Chi-square test for sex variables and smoking status. Ancestry frequencies were expressed as percentage of medium values. BMI body mass index, WC Waist Circumference, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, HDL high density lipoprotein cholesterol, LDL low density lipoprotein cholesterol, TC Total Cholesterol, TG Triglycerides, T2D Type 2 Diabetes, FPG Fasting Plasma Glucose, HbA1c glycated hemoglobin, hsCRP high-sensitivity C-reactive protein.