Table 2.
SNP association under the log-additive genetic model adjusted for confounding variables (Model 1and 2).
| SNP (consequence) | Genotypes | Normal weight N (%) | Excessive weight N (%) | OR (95% CI) M1 | p-value M1 | OR (95% CI) M2 | p-value M2 |
|---|---|---|---|---|---|---|---|
| rs9411207 (intronic) | CC | 116 (41.6%) | 244 (32.8%) | ||||
| CT | 124 (44.4%) | 353 (47.5%) | |||||
| TT | 39 (14%) | 146 (19.7%) | 1.49 (1.21–1.85) | 0.0002 | 1.50 (1.20–1.88) | 0.0002 | |
| rs2229971 (synonymous) | AA | 127 (45.5%) | 266 (35.8%) | ||||
| AG | 114 (40.9%) | 347 (46.8%) | |||||
| GG | 38 (13.6%) | 129 (17.4%) | 1.46 (1.17–1.81) | 0.0005 | 1.44 (1.15–1.81) | 0.0013 | |
| rs11574891 (intronic) | GG | 137 (48.9%) | 304 (40.9%) | ||||
| GA | 123 (43.9%) | 335 (45.0%) | |||||
| AA | 20 (7.1%) | 105 (14.1%) | 1.43 (1.15–1.77) | 0.0012 | 1.41 (1.12–1.77) | 0.0026 | |
| rs3125005 (intronic) | AA | 46 (16.5%) | 93 (12.5%) | ||||
| AG | 132 (47.3%) | 318 (42.8%) | |||||
| GG | 101 (36.2%) | 332 (44.7%) | 1.36 (1.10–1.67) | 0.0038 | 1.35 (1.09–1.69) | 0.0065 | |
| rs3812604 (intronic) | AA | 82 (29.4%) | 168 (22.6%) | ||||
| GA | 133 (47.7%) | 352 (47.4%) | |||||
| GG | 64 (22.9%) | 222 (29.9%) | 1.35 (1.10–1.65) | 0.0041 | 1.38 (1.12–1.71) | 0.0028 | |
| rs3124603 (intronic) | TT | 109 (38.92%) | 249 (33.46%) | ||||
| TC | 122 (43.57%) | 346 (46.50%) | |||||
| CC | 49 (17.50%) | 149 (20.02%) | 1.32 (1.07–1.63) | 0.01 | 1.36 (1.09–1.69) | 0.0068 |
CI Confidence Interval, OR Odds Ratio. Model 1 (M1): Adjusted for age, gender and ancestry; Model 2 (M2): Adjusted for age, gender, ancestry, HDL, triglycerides, hsCRP and HbA1c.