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. 2024 Jun 28;75:103261. doi: 10.1016/j.redox.2024.103261

Fig. 6.

Fig. 6

Nrf2E79Q activation early after DMBA increases the frequency of non-signature H and KRas mutations in tumors. (A) Presence of mutant Ras transcripts in 6 K14CreERtam and 7 K14CreERtam;LSL-Nrf2E79Q/wt skin tumors of early TMX treated mice collected for RNAseq. HrasQ61L mutations were significantly altered in the K14CreERtam;LSL-Nrf2E79Q/wt mice. *Denotes p ≤ 0.05 Fisher's Exact Test. (B) Percentage of the specific mutated Ras isoform mRNA and it's wild type isoform mRNA for each tumor in Fig. 6A. (C) Presence of mutant Ras transcripts in 6 K14CreERtam and 6 K14CreERtam;LSL-Nrf2E79Q/wt skin tumors of late TNX treated mice collected for RNAseq. (D) Percentage of the specific mutated Ras isoform mRNA and it's wild type isoform mRNA for each tumor in Fig. 6C.