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. 2024 Jul 9;12:1412584. doi: 10.3389/fbioe.2024.1412584

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Copyright © 2024 Salamanna, De Luca, Vandenbulcke, Di Matteo, Kon, Grassi, Ballardini, Morozzi, Raimondi, Bellavia, Costa, Zaffagnini, Fini and Giavaresi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vancomycin (A) and Gentamicin (B) released at different timepoints as percentage of the drug initially loaded. The amount of released vancomycin and gentamicin was calculated according to the amount (1 mg) loaded into the G. The (C,D) images represent the boost release of the two antibiotics over a 24-h period. (Mean ± SD, n = 3). Two-ANOVA (F = 134.9, p < 0.0005): Vancomycin release was higher than Gentamicin at 0.5 (p = 0.008); 1 (p = 0.008); and 168 (p = 0.014) hours; Gentamicin release was higher than Vancomycin at 4 (p = 0.008); 6 (p < 0.0005); 24 (p = 0.045); and 48 (p = 0.034) hours.