Figure 4.

Regulation of the amplitude of the metabolites by the amplitude of insulin

(A) Temporal pattern of insulin with different amplitudes as input. The colors of the lines indicate different peaks.

(B) Definition of amplitudes in time series for insulin and metabolites.

(C) Temporal pattern of metabolites as outputs. The colors of the lines correspond to the colors of the inputs (A).

(D) The amplitudes of the indicated metabolite against the amplitudes of insulin in the simulation.

(E) EC₅₀s of metabolites against the amplitude of insulin. The color of the bar indicates the metabolic group (blue: AAs, green: lipids).