Figure 6.

Model validation

Time course data on the mean values of blood insulin and blood metabolites in five individuals by glucose ingestion for validation. The doses and ingestion patterns are indicated at the top. The blue lines indicate the temporal patterns of simulations, and the red circles indicate the time course data of experiments. Before and after glucose ingestion, the concentration of blood insulin and 14 amino acids, including leucine and valine, and 4 lipids, including FFA and ketone bodies were measured at 14 time points from 10 min before fasting to 240 min after glucose ingestion (−10, 0, 10, 20, 30, 45, 60, 75, 90, 120, 150, 180, 210, 240 min).