Table 3.
Between-Group Differences outcomes among Recipients of Mechanical and Biologic Valve in AVR cohort.
| Aortic–valve replacement (50–70 yrs) | Aortic–valve replacement (50–59 yrs) | Aortic–valve replacement (60–70 yrs) | |||||||
| Bioprosthetic (n = 134) | Mechanical (n = 324) | p-value | Bioprosthetic (n = 33) | Mechanical (n = 237) | p-value | Bioprosthetic (n = 101) | Mechanical (n = 87) | p-value | |
| Death | 23 (80.4%) | 49 (81.0%) | 0.500 | 6 (77.0%) | 34 (83.0%) | 0.500 | 17 (81.9%) | 15 (73.2%) | 1.000 |
| (15–yrs survival rate) | |||||||||
| Crude model | ref | 0.83 (0.51–1.37) | 0.469 | ref | 0.73 (0.31–1.75) | 0.482 | ref | 1.00 (0.50–2.00) | 1.000 |
| HR (95% CI) | |||||||||
| IPW model | ref | 1.12 (0.60–2.09) | 0.725 | ref | 1.00 (0.35–2.92) | 0.996 | ref | 1.11 (0.54–2.27) | 0.777 |
| HR (95% CI) | |||||||||
| Cox HR | ref | 0.84 (0.45–1.56) | 0.588 | ref | 0.55 (0.21–1.44) | 0.222 | ref | 1.12 (0.56–2.25) | 0.742 |
| HR (95% CI) | |||||||||
| Stroke (percentage) | 16 (11.9%) | 45 (13.9%) | 0.999 | 3 (9.1%) | 34 (14.3%) | 0.6 | 13 (12.9%) | 11 (12.6%) | 0.800 |
| Crude model | ref | 1.02 (0.57–1.82) | 0.950 | ref | 1.35 (0.41–4.41) | 0.623 | ref | 0.92 (0.41–2.07) | 0.842 |
| HR (95% CI) | |||||||||
| IPW model | ref | 1.39 (0.64–3.02) | 0.405 | ref | 2.02 (0.54–7.56) | 0.296 | ref | 1.31 (0.53–3.22) | 0.554 |
| HR (95% CI) | |||||||||
| Cox HR | ref | 1.09 (0.54–2.18) | 0.808 | ref | 1.098 (0.34–3.60) | 0.878 | ref | 1.69 (0.75–3.80) | 0.203 |
| HR (95% CI) | |||||||||
| Bleeding (percentage) | 10 (7.5%) | 97 (29.9%) | 0.001 | 4 (12.1%) | 76 (32.1%) | 0.06 | 6 (5.9%) | 21 (24.1%) | 0.001 |
| Crude model | ref | 3.97 (2.07–7.62) | 0.001 | ref | 2.54 (0.93–6.95) | 0.07 | ref | 4.31 (1.74–10.71) | 0.002 |
| HR (95% CI) | |||||||||
| IPW model | ref | 2.51 (1.06–5.93) | 0.036 | ref | 2.11 (0.76–6.23) | 0.176 | ref | 3.57 (1.36–9.36) | 0.010 |
| HR (95% CI) | |||||||||
| Cox HR | ref | 3.07 (1.51–6.24) | 0.002 | ref | 2.50 (0.88–7.09) | 0.084 | ref | 3.48 (1.29–9.41) | 0.014 |
| HR (95% CI) | |||||||||
AVR, aortic valve replacement; HR, hazard ratio; CI, confidence interval; Crude model HR, analyzed in the univariate model, inverse probability-weighted (IPW) model HR, analyzed in IPW model; Cox HR: adjusted for demographic features, body mass index (BMI), history of hypertension, hyperlipidemia, diabetes, chronic obstructive pulmonary disease (COPD), stroke, atrial fibrillation (AF), coronary heart disease (CHD) and New York Heart Association (NYHA) class. ref refers to the reference in the model.