Table 3.

Study data used in meta-analyses of virulence factors and invasive infection (lab method: WGS, low ROB).

Virulence factor	No. of studies	No. of iGAS	No. of non-iGAS	Pooled OR	95%CI	Heterogeneity (I2) %	Studies used (reference no.)
speA	1	22/236	79/417	0.44	0.27;0.73	–	(Li et al., 2022)
speC	1	169/236	302/417	0.96	0.67;1.37	–	(Li et al., 2022)
speG	1	219/236	342/417	2.83	1.63;4.92	–	(Li et al., 2022)
speH	1	36/236	78/417	0.78	0.51;1.21	–	(Li et al., 2022)
speI	1	35/236	72/417	0.83	0.54;1.30	–	(Li et al., 2022)
speJ	2	85/259	95/419	1.28	0.89;1.85	0	(Coppens et al., 2019; Li et al., 2022)
speK	2	20/259	98/419	0.26	0.15;0.45	0	(Coppens et al., 2019; Li et al., 2022)
speL	1	18/236	17/417	1.94	0.98;3.85	–	(Li et al., 2022)
speM	1	18/236	17/417	1.94	0.98;3.85	–	(Li et al., 2022)
ssa	1	15/236	132/417	0.15	0.08;0.26	–	(Li et al., 2022)
smeZ	1	162/236	350/417	0.42	0.29;0.61	–	(Li et al., 2022)
NaDase 330G	1	173/236	371/417	0.34	0.22;0.52	–	(Li et al., 2022)
hasA	1	163/236	225/417	1.91	1.36;2.67	–	(Li et al., 2022)
sic	1	24/236	89/417	0.42	0.26;0.68	–	(Li et al., 2022)
sda1	1	36/236	94/417	0.62	0.41;0.94	–	(Li et al., 2022)
pnga3	1	74/236	265/417	0.26	0.19;0.37	–	(Li et al., 2022)

iGAS, invasive GAS infections; non-iGAS, non-invasive GAS infections; OR, odds ratio; CI, confidence interval; bold typeface, significant association