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. 2024 Jul 25;23(Suppl 1):1254. doi: 10.1186/s12885-023-11316-0

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© Merck & Co., Inc., Rahway, NJ, USA and its affiliates 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circulating kynurenine levels^a,b in patients receiving pembrolizumab + epacadostat, pembrolizumab monotherapy, or EXTREME. Kynurenine levels at cycle 1, day 1, and cycle 2, day 1, were compared using a paired Student’s t test within each treatment arm. ns not significant. ^aBlood samples were drawn before administration of any study drug on day 1 of cycle 1 and day 1 of cycle 2. ^bDotted line at 1.5 µM represents the median circulating kynurenine level in healthy subjects [12]