Table 2.
Gene ontology enrichment analysis. This table presents the GO terms that best represent “independent” groups of significant GO terms for gene expression differences between the fast- and slow-growing phenotypes. See supplementary material for complete results of the gene ontology enrichment analysis. Gene ratio indicates the number of significant genes (P value < 0.01) present in a category/total genes belonging to this category. FDR values correspond to an adjusted P value cutoff of 0.05 using the Benjamini–Hochberg method
| GO terms | GO id | Gene ratio | FDR | regulation |
|---|---|---|---|---|
| Ontology: Molecular Function | ||||
| inositol phosphate phosphatase activity | GO:0004445 | 9/22 | 6.63e-04 | Up |
| signaling receptor complex adaptor activity | GO:0030159 | 12/31 | 5.72e-04 | Up |
| cytoskeletal motor activity | GO:0003774 | 66/141 | 3.00e-10 | Up |
| phosphatidylinositol binding | GO:1,901,981 | 87/256 | 3.87e-11 | Up |
| SH3 domain binding | GO:0017124 | 42/108 | 6.43e-04 | Up |
| GTPase binding | GO:0031267 | 216/608 | 6.35e-16 | Up |
| protein kinase activity | GO:0004672 | 162/463 | 8.32e-12 | Up |
| ubiquitin-like protein transferase activity | GO:0004842 | 118/397 | 6.02e-06 | Up |
| calcium ion binding | GO:0005509 | 107/337 | 7.94e-05 | Up |
| cytoskeletal protein binding | GO:0008092 | 290/891 | 4.78e-06 | Up |
| transcription regulator activity | GO:0140110 | 279/995 | 1.46e-04 | Down |
| Catalytic activity, acting on a nucleic acid | GO:0140640 | 126/670 | 3.83e-05 | Down |
| RNA binding | GO:0003723 | 200/966 | 2.33e-20 | Down |
| peptide receptor activity | GO:0001653 | 46/110 | 1.47e-07 | Down |
| oxidoreduction-driven active transmembrane transporter | GO:0003954 | 13/58 | 1.84e-05 | Down |
| structural constituent of ribosome | GO:0003735 | 41/164 | 2.33e-20 | Down |
| Ontology: Biological Processes | ||||
| astrocyte differentiation | GO:0048708 | 21/45 | 3.24e-05 | Up |
| regulation of defense response to bacterium | GO:1,900,424 | 20/68 | 3.92e-04 | Up |
| protein autophosphorylation | GO:0018105 | 112/318 | 6.01e-17 | Up |
| regulation of phosphatidylinositol 3-kinase signaling | GO:0014066; | 39/91 | 2.46e-04 | Up |
| mucopolysaccharide metabolic process | GO:1,903,510 | 27/132 | 5.58e-06 | Up |
| regulation of ERBB signaling pathway | GO:0042058 | 53/159 | 1.56e-06 | Up |
| regulation of TOR signaling | GO:0032006 | 41/141 | 1.72e-04 | Up |
| axo-dendritic transport | GO:0008088 | 60/146 | 1.97e-04 | Up |
| regulation of dephosphorylation | GO:0010921 | 67/177 | 2.96e-04 | Up |
| protein polyubiquitination | GO:0000209 | 89/289 | 1.56e-06 | Up |
| endomembrane system organization | GO:0010256 | 137/557 | 2.21e-04 | Up |
| cell morphogenesis | GO:0000902 | 450/1336 | 5.15e-07 | Up |
| RNA biosynthetic process | GO:0006351 | 186/730 | 1.73e-05 | Down |
| protein-DNA complex subunit organization | GO:0065004 | 53/238 | 9.03e-05 | Down |
| RNA processing | GO:0006396 | 247/1127 | 3.96e-35 | Down |
| ribonucleoprotein complex biogenesis | GO:0022613 | 145/591 | 6.79e-20 | Down |
| neuropeptide signaling pathway | GO:0007218 | 46/110 | 1.37e-08 | Down |
| mitochondrial gene expression | GO:0006414 | 41/189 | 5.33e-16 | Down |
| mitochondrial respiratory chain complex assembly | GO:0010257 | 14/64 | 2.52e-06 | Down |
| regulation of postsynaptic cytosolic calcium ion | GO:0099566 | 7/11 | 3.64e-04 | Down |
| Ontology: Cellular Components | ||||
| endosome | GO:0005768 | 255/870 | 1.05e-15 | Up |
| apical part of cell | GO:0045177 | 188/632 | 7.06e-09 | Up |
| perinuclear region of cytoplasm | GO:0048471 | 235/807 | 1.38e-10 | Up |
| cytoplasmic region | GO:0099568 | 239/693 | 7.62e-08 | Up |
| chromosome | GO:0005694 | 218/980 | 6.66e-06 | Down |
| ribonucleoprotein complex | GO:1,990,904 | 241/978 | 1.43e-25 | Down |
| peptidase complex | GO:0000502 | 23/125 | 2.73e-06 | Down |
| preribosome | GO:0030684 | 28/133 | 2.72e-08 | Down |
| mitochondrial protein-containing complex | GO:0098798 | 51/248 | 3.04e-20 | Down |
| ribosome | GO:0005840 | 54/227 | 5.65e-19 | Down |