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. 2024 Jul 25;26:139. doi: 10.1186/s13075-024-03379-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Increased neutrophil activation and NETs in diffuse cutaneous SSc patients and associate with early disease duration. (A-B) Levels of calprotectin (S100A8/A9) and MPO-DNA complexes were analyzed by ELISA in plasma samples of SSc patients according to their skin phenotype, diffuse cutaneous SSc (n = 87) vs. limited cutaneous SSc (n = 38). (C) Correlation between neutrophil activation and disease duration. (D) Correlation between NET levels in plasma and disease duration. Mean is presented as a horizontal line; ****P < 0.0001 by t-test, and Pearson correlation was computed for C and D