Table 2.
Changes in quality of life 1 year after ICU for different subgroups of ICU patients
| Admission diagnosis | EQ-5D-5L index score before hospital admission Median (IQR) |
EQ-5D-5L index score 1 year after ICU admission Median (IQR) |
P value* | Delta EQ-5D-5L index score** Mean (SD) |
|---|---|---|---|---|
| Cardiovascular (n = 587, 15.0%) | 0.82 (0.59–0.96) | 0.82 (0.70–0.91) | < 0.01 | 0.07 (0.30) |
| - Sepsis/septic shock (n = 230) | 0.72 (0.45–0.88) | 0.78 (0.64–0.88) | < 0.001 | 0.11 (0.34) |
| - Hemodynamic instability (n = 168) | 0.85 (0.70–1.00) | 0.85 (0.76–1.00) | < 0.01 | 0.09 (0.31) |
| - Cardiac arrest (n = 117) | 1.00 (0.84–1.00) | 0.87 (0.74–1.00) | < 0.001 | -0.05 (0.19) |
| - Cardiac (n = 72) | 0.78 (0.60–0.85) | 0.81 (0.69–0.89) | 0.02 | 0.08 (0.24) |
| Cardiovascular surgery (n = 1464, 37.4%) | 0.83 (0.70–0.91) | 0.86 (0.78–1.00) | < 0.001 | 0.07 (0.22) |
| - Thoracic aortic aneurysm (n = 172) | 0.85 (0.74–0.91) | 0.81 (0.74–0.89) | 0.03 | -0.02 (0.21) |
| - Coronary artery bypass grafting (n = 650) | 0.85 (0.72–0.92) | 0.89 (0.79–1.00) | < 0.001 | 0.08 (0.22) |
| - Cardiac valve surgery (n = 506) | 0.81 (0.66–0.89) | 0.88 (0.78–1.00) | < 0.001 | 0.09 (0.23) |
| - Vascular surgery (n = 136) | 0.81 (0.66–0.89) | 0.84 (0.74–0.90) | < 0.01 | 0.07 (0.22) |
| Respiratory (n = 675, 17.2%) | 0.68 (0.31–0.88) | 0.81 (0.67–0.89) | < 0.001 | 0.17 (0.38) |
| - Obstructive pulmonary disease (n = 39) | 0.46 (0.17–0.70) | 0.64 (0.37–0.76) | < 0.01 | 0.16 (0.34) |
| - Pneumonia (n = 140) | 0.63 (0.30–0.81) | 0.73 (0.60–0.85) | < 0.001 | 0.15 (0.32) |
| - COVID-19 (n = 440) | 0.74 (0.33–0.89) | 0.84 (0.72–0.91) | < 0.001 | 0.18 (0.39) |
| - Other respiratory (n = 56) | 0.74 (0.30–0.88) | 0.79 (0.63–1.00) | 0.01 | 0.13 (0.43) |
| Neurological (n = 186, 4.7%) | 0.82 (0.55–0.91) | 0.80 (0.62–0.89) | 0.55 | 0.01 (0.36) |
| - Intracerebral hemorrhage (n = 67) | 0.89 (0.76–1.00) | 0.81 (0.63–0.88) | 0.05 | -0.08 (0.29) |
| - Cerebrovascular accident (n = 20) | 0.75 (0.62–0.86) | 0.75 (0.54–0.83) | 0.43 | -0.09 (0.42) |
| - Neurosurgery (n = 45) | 0.78 (0.42–0.88) | 0.73 (0.36–0.85) | 0.53 | 0.02 (0.38) |
| - Other neurological (n = 54) | 0.71 (0.45–0.91) | 0.84 (0.66–0.91) | < 0.01 | 0.15 (0.36) |
| Trauma (n = 184, 4.7%) | 1.00 (0.82–1.00) | 0.82 (0.61–0.89) | < 0.001 | -0.13 (0.28) |
| - Neurotrauma (n = 87) | 1.00 (0.85–1.00) | 0.84 (0.65–0.92) | < 0.001 | -0.13 (0.26) |
| - Other trauma (n = 97) | 1.00 (0.79–1.00) | 0.81 (0.57–0.89) | < 0.001 | -0.13 (0.29) |
| Other (n = 817, 20.9%) | 0.81 (0.60–0.89) | 0.82 (0.74–0.91) | < 0.001 | 0.08 (0.26) |
| - Metabolic or endocrine (n = 41) | 0.81 (0.63–0.89) | 0.80 (0.67–0.89) | 0.52 | 0.07 (0.32) |
| - Chest surgery (n = 110) | 0.82 (0.66–0.91) | 0.85 (0.78–0.98) | < 0.01 | 0.06 (0.21) |
| - Oncologic surgery (n = 385) | 0.81 (0.66–0.89) | 0.84 (0.74–0.92) | < 0.001 | 0.05 (0.23) |
| - Other (n = 281) | 0.74 (0.51–0.86) | 0.81 (0.70–0.89) | < 0.001 | 0.12 (0.29) |
*Comparison of EQ-5D-5L index score before hospital admission and EQ-5D-5L index score 1 year after ICU admission, using Wilcoxon signed rank test
**Clinically relevant changes in quality of life (≥ 0.08, based on MCID) are shown in bold