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. Author manuscript; available in PMC: 2024 Jul 25.
Published in final edited form as: SLAS Discov. 2019 Oct 29;25(3):265–276. doi: 10.1177/2472555219880194

Figure 3.

Figure 3.

Comparison of pharmacological effects of compounds on 3D heterotypic multicellular tumor spheroids of different cancer types. A) The heat map illustrates size-based % maximal responses at 20 μM drug concentrations calculated over time from HEY/NIH, PANC/NIH and SKOV/NIH microtissues. Darkest red indicates 100 % growth for tissue size data. Darkest blue indicates 0 % growth for tissue size data. For % maximal response calculations tissue size values were normalized to the vehicle control. Correlation plots of logAC50 between different tumor microtissue types using ATP 7 days as a readout (B-D), and between ATP and tissue size at 7 days, for each cancer microtissues (E-G).