Fig. 5. Late-stage functionalization and scale-up experiments.

a Modification of pharmaceutical derivatives. ^aGeneral reaction conditions: alkene (0.2 mmol), (CF₃CO)₂O (1.0 mmol), Selectfluor (0.3 mmol), Fe(acac)₃ (0.02 mmol), oxydibenzene (0.1 mmol), isopropanol (0.4 mmol) and CH₃CN (0.1 M), N₂, blue LEDs, 12-h reaction time. ^bBlue LEDs, 24-h reaction time. b Gram-scale and TON experiments. Condition A: alkene (62, 5.0 mmol), (CF₃CO)₂O (25.0 mmol), Selectfluor (7.5 mmol), Fe(acac)₃ (0.5 mmol), oxydibenzene (2.5 mmol), isopropanol (10.0 mmol) and CH₃CN (50.0 mL), N₂, blue LEDs, 72-h reaction time. Condition B: alkene (62, 2.0 mmol), (CF₃CO)₂O (10.0 mmol), Selectfluor (3.0 mmol), Fe(acac)₃ (0.006 mmol), oxydibenzene (1.0 mmol), isopropanol (4.0 mmol) and CH₃CN (20.0 mL), N₂, blue LEDs, 144-h reaction time. TON turnover number.