TABLE 1.

Activity of bicyclam derivatives and SDF-1α against fusion between FIV-infected CRFK cells and HeLa cells, against HIV-1 IIIB replication in MT-4 cells, against replication of FIV-113cr in CRFK cells, and against FIV-113th replication in feline thymocytes

Compound	IC50 (μg/ml) for:				Ratio of IC50 of FIV-113th to IC50 of FIV-113cr
	Fusion of FIV-infected CRFK and HeLa cells	HIV-1 IIIB in MT-4 cells	FIV-113cr in CRFK cells	FIV-113th in thymocytes
AMD2763	0.56	0.78	0.94	66.5	77
AMD3100	0.055	0.009	0.014	0.062	4
AMD3479	0.007	0.008	0.008	0.139	17
AMD3122	15.6	20.9	47.6	>100	>2
AMD3165	0.065	0.006	0.013	0.40	31
AMD3167	0.008	0.006	0.002	0.34	170
AMD3462	0.030	0.02	0.02	0.64	32
AMD6038	0.039	0.07	0.057	6.0	105
AMD6171	0.036	0.14	0.109	4.4	40
AMD3106	0.063	0.04	0.108	6.2	57
AMD3108	10.7	3.1	6.4	50.4	8
AMD6174	0.038	0.06	0.043	1.9	44
SDF-1α	0.170	0.150	0.200	>2.5	>12