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. 2024 Jul 20;15:6124. doi: 10.1038/s41467-024-50477-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cartoon representation of the trimeric arrangement of insulin icodec in the crystal. The dimer is coloured in orange and dark blue, for A-chain and B-chain, respectively. The additional icodec molecule is coloured in yellow (A-chain) and purple (B-chain). b Superposition of icodec molecule 1 with molecule 3 of the icodec trimer (left) and icodec molecule 1 with human insulin (right). Colours for icodec are as in (a); human insulin is in light yellow (A-chain) and cyan (B-chain). Residues A14, B16 and B25, which differ between human insulin and icodec are depicted in stick representation. c Interactions (dashed lines) around the A20-B19 disulphide bond for insulin icodec molecule 1 (1st from the left), insulin icodec molecule 3 (2nd from the left), human insulin (3rd from the left) and OI338 (4th from the left).