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. 2024 Jun 10;30(7):2037–2048. doi: 10.1038/s41591-024-03018-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Relative liver fat reduction. Results are shown as LSM ± s.e.m. (n = 19 (PBO), n = 20 (1 mg RETA), n = 19 (4 mg RETA), n = 22 (8 mg RETA) and n = 18 (12 mg RETA)). b, The percentage of participants achieving liver fat reduction targets at week 24. c, The percentage of participants achieving liver fat content <5%. Comparisons versus PBO were done by using two-sided z-tests without multiplicity adjustment. *P < 0.05 versus PBO; ***P < 0.001 versus PBO; #, not calculable. Fewer participants had MRIs at week 48 (n = 8 (PBO), n = 9 (1 mg RETA), n = 9 (4 mg RETA), n = 8 (8 mg RETA) and n = 9 (12 mg RETA)) compared with week 24 (n = 14 (PBO), n = 16 (1 mg RETA), n = 15 (4 mg RETA), n = 17 (8 mg RETA) and n = 15 (12 mg RETA)).