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. 2024 Jun 10;30(7):2037–2048. doi: 10.1038/s41591-024-03018-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Data for all participants is shown, excluding data after discontinuation of treatment. One of the participants in the 8 mg dose group missed the last two doses of retatrutide, despite being marked as treatment completed by the investigator. This may have contributed to the lesser relative liver fat reduction at week 48 (−68.5%) compared with week 24 (−84.5%) for this participant.