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. 2024 Jun 10;30(7):2037–2048. doi: 10.1038/s41591-024-03018-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, The percentage change in body weight. b, The percentage change in waist circumference with results shown as LS means (SE). Comparisons vs. PBO were done by using 2-sided z-tests without multiplicity adjustment. *p<0.05 vs. PBO; **p<0.01; ***p<0.001 vs. PBO. Results at the 48-week end-of-treatment visit are shown with statistical testing results. Additionally, 4-week post-treatment results are shown. LS, least squares; PBO, placebo; RETA, retatrutide; SE, standard error.