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. 2024 Jun 6;30(7):1913–1922. doi: 10.1038/s41591-024-03044-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, b, Evaluable response and objective clinical benefit (OCB) rate by (a) tier of PGT recommendation and (b) stratified by types of molecular aberration. c, The number of PGTs with and without OCB for each specific RNA targets or pathways. d, e, Evaluable response and OCB rate by (d) progressive disease (PD) from enrolment to the start of PGT and (e) number of favorable prognostic factors. Chi-square test is used to compare evaluable response and OCB rate between 2 groups and the actual P values are presented in Table 1. The P value shown in panel (d) is for Chi-square test for trend. CNV, copy number variation; CR, complete response; PR, partial response; PD, progressive disease; SD, stable disease; SNV, single nucleotide variant; SV, structural variant.