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. 2024 Jun 6;30(7):1913–1922. doi: 10.1038/s41591-024-03044-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a,b, PFS (a) and OS (b) stratified according to PGT and non-PGT commenced at any point after MTB discussion. c,d, PFS (c) and OS (d) stratified according to PGT and UGT, that is, new therapy not molecularly guided. e, Response to PGT and UGT in patients with evaluable disease. f, OCB rate in PGT and UGT. OCB was defined as CR, PR and SD of 24 weeks’ duration or longer, and ongoing CR of 24 weeks or longer for patients who were in CR at the start of treatment. A two-sided chi-squared test was used to compare the CR and PR rate in e and OCB rate in f. g,h, PFS (g) and OS (h) stratified according to PGT and SOC. For OS comparison, a patient was categorized according to the first treatment that was initiated after MTB discussion. The Kaplan–Meier survival curves were compared using a two-sided log-rank test.