Extended Data Fig. 4. Swimmer plot of 44 precision-guided treatments (PGTs) which did not lead to objective clinical benefit (OCB).

Lack of OCB includes patients with disease at the start of treatment who had stable disease (SD) for <24 weeks duration or progressive disease (PD) and patients in complete remission (CR) at the start of treatment with relapse-free duration <24 weeks. The color of the bars indicates tier of a PGT recommendation. Symbols indicate responses and treatment status. The diagnosis and molecular targets for each patient are shown. The types of molecular aberration are denoted by different color text. Fusion or structural variant (SV) is shown in blue, single nucleotide variants in red, high RNA expression in green, copy number variant in brown and other alterations in black.