Extended Data Fig. 4. Overview of the PORTEC-3 randomized trial and analysis of treatment response prediction by HECTOR.

In PORTEC-3, 660 evaluable patients were randomized (1:1) between adjuvant external beam radiotherapy (EBRT) alone and external beam radiotherapy in combination with concurrent and adjuvant chemotherapy (CT). For 442 patients whose WSI was available, HECTOR risk scores were inferred. HECTOR risk groups cutoffs were kept the same as the training set (Methods).