Fig. 5. Frequency of diagnoses across biotypes.

We show the proportion of participants in each biotype who meet diagnostic criteria for major depressive disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder and post-traumatic stress disorder (biotypes are labeled a–f). χ² tests revealed that the frequency of major depressive disorder was significantly different across biotypes (two-sided χ² = 24.235, P = 0.0002). We used the same biotype nomenclature as previously. The subscript x indicates that the sixth biotype is not differentiated by a prominent circuit dysfunction relative to other biotypes. Besides this nomenclature, we suggest a short plain-English description for each biotype (in quotes), which connects them with our theoretically synthesized biotypes, again as expressed in the legend to Fig. 3.