Table 3.
Performance of BD Phoenix™, Vitek®2 and Etest® compared to broth microdilution for the determination of susceptibility to penicillin, amoxicillin and cefotaxime of 60 S. pneumoniae strains. Each testing method was performed in 2 different labs
| penicillin | amoxicillin | cefotaxime | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Testing method | EA (%) | CA (%) | VME (n) | ME (n) | mE (n) | bias (%) |
EA (%) | CA (%) | VME (n) | ME (n) | mE (n) | bias (%) |
EA (%) | CA (%) | VME (n) | ME (n) | mE (n) | bias (%) |
| BD Phoenix™ | 90.8 | 82.5 | 1 | 15 | 5 | + 19.9 | 99.2 | 88.3 | 0 | 12 | 2 | + 7.1 | 100 | 87.5 | 3 | 0 | 12 | -24.8 |
| Vitek®2 | 96.6 | 90.0 | 6 | 0 | 6 | -8.7 | 91.7 | 86.7 | 0 | 16 | 0 | + 18.3 | 99.2 | 90.0 | 0 | 5 | 7 | + 7.5 |
| Etest on Oxoid plate | 58.3 | 74.2 | 31 | 0 | 10 | -73.0 | 65.8 | 75.8 | 19 | 2 | 8 | -72.0 | 90.8 | 79.2 | 4 | 0 | 21 | -35.1 |
| Etest on BD BBL plate | 94.2 | 84.2 | 12 | 1 | 6 | -20.4 | 84.2 | 82.5 | 7 | 10 | 4 | -27.7 | 95.0 | 87.5 | 1 | 2 | 12 | + 7.9 |
EA, essential agreement; CA, categorical agreement; VME, very major error; ME, major error; mE, minor error
aEUCAST 2023 clinical breakpoints for indications other than meningitis were used to interpret the results
bCLSI and ISO acceptance rates (EA and CA ≥ 90%, difference bias ± 30%) are in bold