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. 2024 Jul 20;15(7):518. doi: 10.1038/s41419-024-06910-4

Fig. 1. Compromised NK cell activities by decreased UCP1 in NAFLD individuals.

Fig. 1

A NK cell frequency and phenotype in slight or moderate NAFLD patients. B UCP1 levels in peripheral NK cells. C Correlations of UCP1 levels with IFN-γ and GZB productions of NK cells. D UCP1 of NK cells stimulated with IL-2 and IL-15 ex vivo. E UCP1 of NK cells from MCD-fed mice. F Liver droplets stained by oil red. G Serum AST and ALT, and liver TG, TC and FFAs. H Detection of hepatic NK cells. NKG2D, IFN-γ, GZB (I) of hepatic NK cells. J NK cell apoptosis detected by flow cytometry. K Liver sections stained by Masson and Sirius red. L Variations of macrophages in liver and spleen. M NK cell cytotoxicity against macrophages. Human NK cells were isolated from peripheral blood, and mouse NK cells were isolated from spleen. All animal and cell experiments were repeated at least twice. Ns no significance; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.