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. 2024 Jul 22;9:132. doi: 10.1038/s41541-024-00924-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Mice (n = 12/group) were immunized twice, 3 weeks apart, with the specified CoV RBDs formulated with Alum+CpG55.2. a–h The neutralization of pan-coronavirus pseudoviruses was assessed using pooled sera for each group. The X-axis denotes the vaccine antigens, while the Y-axis represents neutralizing titers (IC50). Each data point reflects the mean IC50 values obtained from duplicate independent serum dilution series.