TABLE 1.

Kinetics of all and virus-expressing thymocyte precursors after infection with the HIV reporter virus^a

No. of wks postinfection	No. of mice		Mean % of CD4/CD8 cells +/− SE in:		P value		Mean % of CD4/CD8/HSA cells +/− SE in:		P value
	Untreated	Treated	Untreated mice	Treated mice	Rank sum test	ANOVA	Untreated mice	Treated mice	Rank sum test	ANOVA
7	12	15	9.7 ± 6.9	7.2 ± 3.7			13.5 ± 3.7	16.5 ± 2.7
10	12	15	11.4 ± 5.6	41.8 ± 7.4	0.002	0.02	18.3 ± 3.9	4.6 ± 1.8	0.008	0.09
15	9	10	1.2 ± 0.8	21.5 ± 9.9	0.003		0	6.2 ± 3.9	0.003
18	5	6	7.2 ± 6.1	8.9 ± 2.8	0.796		17.3 ± 16.3	27.6 ± 12.3	0.195

^aAnimals were infected at day 0, and triple-drug therapy was begun at week 8. Flow cytometry was done at week 7 for both cohorts, which were separated by intention to treat. Analysis of HSA expression in DP CD4/CD8 thymocytes for the untreated group at week 18 included three animals, as two of the five implants were completely devoid of DP thymocytes at that time point. Significance values are provided for each time point after the initiation of drug treatment (rank sum test) and for the overall drug × time interaction effect on differences in the profile of results over all time points (ANOVA).