Table 2.

C-codes reported in pathogenic/likely pathogenic DICER1 heterozygotes in the UK Biobank and Geisinger cohorts

UK Biobank
	DICER1 Variant	Sex	Age (y)	ICD9/10	Age at Cancer (y)	Vital Status
UKB1	p.(Asp1414fs)	Female	78	C92.0 Acute myeloid leukemia	77	Died 78.1 (due to AML)
UKB2	p.(Ser1344fs)	Female	57	1944 Pineoblastoma	15
				D32.0 Meningiomac	50
UKB3	p.(Ser1216fs)	Female	64	630 Choriocarcinoma	23
UKB4	p.(Phe854fs)	Female	72	C50.5 Breast cancer	62
UKB5	p.(Tyr936a)	Female	81	1744 Breast cancer	50
UKB6	p.(Leu303fs)	Female	67	C50.4 Breast cancer	56	Died 67 (due to breast cancer)
UKB7	p.(Cys1584fs)	Male	76	C61 Prostate cancer	67
				C44.4 Skin cancer, squamous cell carcinoma	71
UKB8	p.(Gln105a)	Female	72	C25.1 Pancreatic cancer	68	Died 72 (due to pancreatic cancer)
UKB9	p.(Glu221a)	Female	79	C56 Ovarian cancer	58
				C50.4 Breast cancer	68
UKB10	p.(Val121fs)	Male	76	C91.1 Chronic lymphocytic leukemia	72	Died 76
UKB11	p.(Ser1629fs)	Female	69	C44.3 Skin cancer, basal cell carcinoma	47
UKB12	p.(Ser1101fs)	Male	67	C43.6 Skin cancer, superficial spreading melanoma	62

Geisinger
	DICER1 Variant	Sex	Age (y)	ICD10	Age at Cancer (y)	Vital Status
GHS1	c.4050+1G>A	Female	62	C50.2 Breast cancer	54
GHS2a	p.(Asn1668fs)	Male	55	C73.9 Papillary thyroid cancer	36
GHS3a	p.(Ser1823fs)	Female	44	C75.3 Pineoblastoma	14	Died 44
				C70.0 Meningioma	41
GHS4b	p.(Glu128fs)	Male	67	C34.1 Lung cancer	62
GHS5b	p.(Glu128fs)	Female	65	C34.3 Lung cancer	54

AML, acute myeloid leukemia.

Please refer to Supplemental Table 2 for additional variant information.

^aPreviously reported.

^bRelated individuals.

^cMeningioma found in this participant was reported in Cancer Registry with malignant histology.