FIG. 2.

Effect of nucleotide changes in d(−1/13) on the ability of the resultant DNA template to compete for RdRp. An RNA template, r(−20/15), directing the synthesis of a 15-nt product, was used as a reference. The amounts of RNA synthesis generated from r(−20/15) in the presence of the different competitors are listed as percentages relative to synthesis in the absence of competitor. DNA competitors were used at 5- and 10-fold molar excess with respect to r(−20/15). All results were from at least three independent trials. ND, not determined.