TABLE 1.

Mutations in endscripts can affect the ability to interact with RdRp

Construct	3′ Sequencea	IC50 (nM)
B2(−)46G	3′ GCAUUU… N46 5′	120
B2(−)Δ−1	3′ -CAUUU… N46 5′	>250
B2(−)Δ−1,+1,+2	3′ ---UUU… N44 5′	>250
B2(−)+1C/G	3′ GGAUUU… N46 5′	>250
B2(−)+2A/G	3′ GCGUUU… N46 5′	235
B2(−)+3U/A	3′ GCAAUU… N46 5′	140
Nonspecific RNA	3′ AUAGGU… N53 5′	>250

^aNucleotides in bold indicate a change from the wild-type sequence.