Table 2. Univariate Cox regression analysis of overall survival in the training cohort.

	Hazard rate (95%CI)	p-value
Age
<18	1.00
18-65	2.12 (1.13-3.94)		0.018
66-79	7 (3.74-13.1)	<0.001
≥80	13.49 (7.12-25.56)	<0.001
Race
White	1.00
Black	0.9 (0.72-1.12)		0.347
Other	0.73 (0.59-0.9)		0.004
Gender
Male	1.00
Female	0.96 (0.87-1.05)		0.347
Laterality
Left	1.00
Right	1.08 (0.98-1.19)		0.1
Not a paired site	1.55 (1.34-1.79)	<0.001
Site
Frontal lobe	1.00
Temporal lobe	1.55 (1.38-1.75)	<0.001
Parietal lobe	1.58 (1.38-1.79)	<0.001
Occipital lobe	2.07 (1.67-2.57)	<0.001
Overlapping lesion	1.82 (1.59-2.09)	<0.001
Histological
Mixed glioma	1.00
Astrocytoma	1.67 (1.26-2.21)	<0.001
Glioblastoma	5.74 (4.38-7.52)	<0.001
Oligodendroglioma	0.87 (0.63-1.18)		0.365
Surgery
Yes	1.00
No	2.07 (1.85-2.31)	<0.001
Radiotherapy
Yes	1.00
No	1.12 (1-1.25)		0.057
Radiation sequence with surgery:
Prior to surgery	1.00
After surgery	1 (0.52-1.93)		0.995
Before and after	1.36 (0.46-4.07)		0.579
Unknown	1.36 (0.71-2.63)		0.358
Chemotherapy
Yes	1.00
No	1.31 (1.19-1.45)	<0.001
Marital
Married	1.00
Single	0.49 (0.43-0.57)	<0.001
Separated/Divorced	1.16 (1-1.35)		0.058
Widowed	2.71 (2.33-3.15)	<0.001
Size (mm)
<26	1.00
27-44	1.01 (0.9-1.14)		0.866
>44	0.88 (0.68-1.09)		0.054
Grade
Grade I+II	1.00
Grade III+IV	3.88 (3.12-4.83)	<0.001