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Three different crystal form structures known to FXR (PDB ID is 4QE6). (A) Common architecture of FXR. (B) The approximate location of the apo-FXR and its bonded pocket that employs different conformation according to the species of ligands. (C) Activated conformation of FXR combined with CDCA (agonist-FXR). (D) Antagonistic conformation of FXR binding to GUDCA (antagonist-FXR).
