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. 2024 Aug 1;15(4):1784–1812. doi: 10.14336/AD.2023.0924

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Copyright: © 2024 Tao et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Age-related changes in MRC subunit activity in bone-related cells. The activities of osteoblasts, osteoclasts, and chondrocytes are significantly decreased during aging. This decrease is accompanied by downregulation of MRC subunit activity in bone-related cells due to the intrusion of various abnormal metabolic factors or harmful substances in the body. This obstruction of MRC affects cellular energy metabolism and intracellular redox signaling, ultimately accelerating pathological bone deterioration.