Table 2.
Clusters with significantly decreased GMVs in the AD group relative to the NC group (Cluster 1) after adjusting for TIV, age, and gender; larger GMVs in females than males (Clusters 2-7) after adjusting for TIV and age; larger GMVs associated with larger TIVs (Clusters 8) after adjusting for age and gender.
| Cluster | N voxels | Peak-t | Peak-t MNI coordinates | Anatomical locations | %Cluster | %Region | |
|---|---|---|---|---|---|---|---|
| 1 | Temporal pole [L] (NC>AD) |
1178 | 4.08 | -38, 12, -20 | Temporal Lobe Temporal_Pole_Sup_L Temporal_Mid_L Temporal_Sup_L Temporal_Inf_L Temporal_Pole_Mid_L Insula Insula_L Frontal Lobe Frontal_Inf_Orb_L |
29.56 21.57 8.52 8.26 3.20 11.58 3.99 |
17.28 3.28 2.79 1.94 3.18 4.68 1.78 |
| 2 | Female > Male |
1905 |
4.82 | -2, 27, -28 | Frontal Lobe Rectus_R Rectus_L Frontal_Sup_Orb_R Frontal_Sup_Orb_L lfactory_R |
24.54 29.61 6.88 6.69 0.37 |
35.44 24.78 7.42 7.48 1.38 |
| 3 | 1097 | 4.23 | -36,-51, -15 | Occipital Lobe Fusiform_L Occipital_Inf_L Temporal Lobe Temporal_Inf_L Cerebelum Cerebelum_6_L |
76.75 6.83 12.31 3.80 |
21.86 4.78 2.53 1.47 |
|
| 4 | 1007 | 4.01 | 56, 12, 3 | Frontal Lobe Frontal_Inf_Oper_R Rolandic_Oper_R Frontal_Inf_Tri_R Temporal Lobe Temporal_Pole_Sup_R Temporal_Sup_R Insula Insula_R |
36.67 22.00 1.61 14.67 7.69 11.27 |
14.65 9.24 0.42 6.13 1.37 3.56 |
|
| 5 | 1189 | 4.75 | 34, -69, 15 | Temporal Lobe Temporal_Mid_R Occipital Lobe Occipital_Mid_R Occipital_Sup_R Cuneus_R Parietal Lobe Precuneus_R |
40.51 17.63 5.11 2.56 3.50 |
6.83 6.24 2.69 1.33 0.80 |
|
| 6 | 1498 | 4.12 | -26,-48, 66 | Parietal Lobe Parietal_Sup_L Precuneus_L Precuneus_R Postcentral_L Parietal_Inf_L Occipital Lobe Cuneus_R |
54.15 28.56 4.01 2.96 1.91 1.24 |
27.46 8.47 1.29 0.80 0.82 0.91 |
|
| 7 | 1357 | 4.10 | -38,-15, 66 | Frontal Lobe Precentral_L Frontal_Sup_L |
80.03 9.16 |
17.83 2.00 |
|
| 8 | Increased with TIV | 226769 | 7.06 | -2, 27, -27 | Frontal Lobe Frontal_Mid_L Frontal_Mid_R Frontal_Sup_R Frontal_Sup_L Precentral_L Frontal_Sup_Medial_L Frontal_Sup_Medial_R Supp_Motor_Area Frontal_Inf_Orb_L Frontal_Inf_Orb_R Frontal_Mid_Orb_R Rolandic_Oper_R Rectus_L Frontal_Sup_Orb_L Frontal_Med_Orb_R Frontal_Inf_Tri_R Frontal_Mid_Orb_L Supp_Motor_Area_L Frontal_Inf_Tri_L Rectus_R Frontal_Med_Orb_L Frontal_Sup_Orb_R Rolandic_Oper_L Frontal_Inf_Oper_R Precentral_R Olfactory_R Olfactory_L Frontal_Inf_Oper_L Temporal Lobe Temporal_Mid_R Temporal_Inf_R Temporal_Mid_L Temporal_Inf_L Temporal_Sup_L Temporal_Sup_R Temporal_Pole_Sup_R Temporal_Pole_Mid_R Temporal_Pole_Sup_L Amygdala_R Heschl_L Temporal_Pole_Mid_L Heschl_R Occipital Lobe Occipital_Mid_L Fusiform_R Calcarine_L Fusiform_L Occipital_Mid_R Calcarine_R Cuneus_L Lingual_R Cuneus_R Occipital_Sup_L Occipital_Sup_R Occipital_Inf_R Lingual_L Occipital_Inf_L Parietal Lobe Precuneus_R Precuneus_L Parietal_Sup_L SupraMarginal_R Angular_R Postcentral_L Parietal_Inf_L Parietal_Sup_R Parietal_Inf_R Angular_L Postcentral_R Paracentral_Lobule_R SupraMarginal_L Paracentral_Lobule_L Insula Insula_R Insula_L Cerebelum Cerebelum_Crus1_R Cerebelum_8_R Cerebelum_6_R Cerebelum_Crus2_R Cerebelum_6_L Cerebelum_Crus1_L Cerebelum_9_L Cerebelum_7b_R Cerebelum_4_5_L Cerebelum_8_L Cerebelum_4_5_R Cerebelum_9_R Cerebelum_Crus2_L Vermis_4_5 Vermis_6 Cerebelum_7b_L Limbic Lobe Cingulum_Mid_L Cingulum_Mid_R Cingulum_Ant_L ParaHippocampal_R Cingulum_Ant_R Cingulum_Post_L Hippocampus_R Cingulum_Post_R Hippocampus_L ParaHippocampal_L Basal Ganglia Thalamus_R Caudate_L Putamen_R Caudate_R Putamen_L Pallidum_L Pallidum_R |
2.82 2.55 2.21 1.70 1.70 1.59 1.14 1.14 1.00 0.93 0.76 0.75 0.73 0.71 0.71 0.69 0.68 0.68 0.66 0.64 0.61 0.60 0.47 0.44 0.39 0.24 0.23 0.15 2.56 2.46 2.01 1.70 1.24 1.20 0.63 0.50 0.26 0.21 0.18 0.15 0.14 2.36 1.77 1.45 1.37 1.35 1.03 1.01 1.00 0.98 0.91 0.87 0.75 0.73 0.69 2.24 2.09 1.11 1.07 1.05 0.97 0.96 0.93 0.65 0.55 0.47 0.37 0.31 0.04 1.23 0.95 1.05 0.94 0.69 0.54 0.44 0.39 0.24 0.15 0.12 0.10 0.10 0.02 0.01 0.01 0.01 0.01 1.01 0.91 0.60 0.53 0.52 0.38 0.33 0.27 0.07 0.02 0.34 0.24 0.18 0.15 0.09 0.02 0.01 |
67.65 58.37 63.44 55.40 56.26 62.13 62.56 56.13 69.17 64.08 87.49 66.49 100.00 86.91 96.96 37.47 89.52 36.75 30.72 99.86 98.75 70.71 56.26 37.31 13.49 98.27 97.50 17.05 67.61 80.52 47.47 62.09 63.02 44.69 55.15 49.36 23.73 99.19 94.22 23.31 65.46 84.25 82.24 75.24 69.52 75.21 64.53 77.71 50.86 80.89 78.33 72.18 89.28 41.09 85.97 79.88 68.99 62.95 63.22 70.37 29.08 46.13 49.32 56.65 54.99 14.54 52.39 28.42 3.11 81.41 59.84 46.49 47.57 44.85 29.57 30.46 17.55 32.80 32.96 12.62 6.46 13.70 2.97 1.16 1.80 3.23 1.71 60.99 48.66 50.00 55.03 45.85 94.82 40.70 94.93 8.47 2.45 37.18 29.00 20.21 17.91 10.40 9.21 2.14 |