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. 2024 Aug 1;15(4):1748–1770. doi: 10.14336/AD.2023.1201

Figure 1.

Figure 1.

Key blood-brain barrier ion transport systems. Ion transporters and channels expressed within the BBB mediates the movement of Na+, K+, Cl-, HCO3-, H+ and Ca2+ into and out of the BBB specific cells. The BBB ion transport is important for regulation of key ionic concentrations in the brain (H+, K+, Ca2+), the uptake and extrusion of trace metals, fluid secretion, intracellular volume, pH and Ca2+ homeostasis.