Table 3.
Frequencies of low- and high-risk HLA genotypes associated with the development of T1D in patients with CD
| High-risk and low-risk HLA genotypes | HLA genotypes | CD (n = 746) | CD-T1D (n = 76) | Percentage of T1D in CD | T1D onset before or at the same time of CDb | T1D onset after CDb |
| High-riska | DQ2.5/DQ8 | 57 | 30 | 34.5% | 22 | 8 |
| DQ2.5/DQ2.5 | 153 | 29 | 15.9% | 20 | 9 | |
| DQ2.5/DQ2.3 | 13 | 3 | 18.8% | 2 | 1 | |
| Low-risk | Other HLA genotypes | 523 | 14 | 2.6% | 10 | 4 |
CD-T1D, celiac disease type 1 diabetes; HLA, human leukocyte antigen.
a
The group of high-risk HLA genotypes was further subdivided by each individual susceptibility HLA genotype for T1D.
b
The last 2 columns report the number of patients who developed T1D before and after CD.