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. Author manuscript; available in PMC: 2024 Jul 25.
Published in final edited form as: Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887

Figure 4: PI3Kγ inhibition suppresses gene expression signatures of inflammation and tissue damage during SARSCoV-2 infection.

Figure 4:

(A and B) Heatmap (A) and gene set enrichment signatures (B) of differentially expressed genes and pathways in SARS-CoV-2 infected, vehicle- or IPI-549-treated mouse lungs at day 5 post-infection. Select gene names are shown. (C) Cell type enrichment signatures expressed in lungs from (A). Cell types shown in grey are not significantly changed in lungs from IPI-549 treated animals. (D) Transcripts per million of myeloid cell genes Pik3cg Adgre1, Cd68, Ly6c2 and Itgam) are shown for lungs from (A). (E) Gene enrichment signatures common to mouse and human SARS-CoV-2 infected lungs that are down-regulated in IPI-549-treated lungs. (F) Heatmap of differentially expressed genes that are upregulated in SARS-CoV-2-infected, IPI-549-treated mouse lungs versus SARS-CoV-2-infected human and mouse lung tissues. Statistical analysis was performed by limma-vroom.