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. 2024 Jul 12;15:1426446. doi: 10.3389/fphar.2024.1426446

FIGURE 5.

FIGURE 5

Ratios of (A) retina:plasma (n = 11 eyes for all treatment groups) and (B) vitreous:plasma, (n = 10 eyes for the vehicle plus phosphate-buffered saline (PBS) group, n = 11 eyes for all other treatment groups), and (C) plasma levels of fluorescein (n = 6 mice) in mice treated with and without intravitreal (IVT) lipopolysaccharide (LPS) and/or twice daily (BID) oral RG7774 (6 mg/kg/day or 20 mg/kg/day). (D) Representative fundus fluorescein angiography (FFA) images (Heidelberg Spectralis) of study eyes from mice treated with and without LPS and/or twice daily oral RG7774 (6 mg/kg/day or 20 mg/kg/day). In (D), mouse identification numbers and left/right eye labels are shown above each image. *p < 0.05; **p < 0.01; ***p < 0.001 based on 1-way analysis of variance (ANOVA), followed by Newman–Keuls post hoc analysis.